The cross reactivity of SRP6155 human BMP2 with rat has not been checked. However, literature indicates a high level of sequence homology between human and rat BMP2 (Freire et al., 2012; Freire et al., 2015) and VEGFA (Avivi et al., 1999; Ferrara, 2002) proteins. Accordingly, in many studies, human recombinant BMP2 and VEGFA have been used successfully in bone regeneration experiments in the rat (Park et al., 2003; Li et al., 2016). It is likely that SRP6155 should work with rat samples.
SRP6155
BMP-2 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(e):
BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Empfohlene Produkte
Biologische Quelle
human
Rekombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
Form
lyophilized
Wirksamkeit
20-100 ng/mL ED50
Mol-Gew.
30-38 kDa (homodimer, glycosylated)
Verpackung
pkg of 10 μg
Methode(n)
cell culture | mammalian: suitable
NCBI-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... BMP2(650)
Allgemeine Beschreibung
BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine.[1] BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
Anwendung
BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.[2]
Biochem./physiol. Wirkung
BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues.[3] During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells.[4] In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.[5]
Physikalische Form
Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Angaben zur Herstellung
Centrifuge the vial prior to opening.
Rekonstituierung
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Nam Hee Kim et al.
Biomaterials, 35(37), 9888-9896 (2014-09-15)
Though growth factors allow tissue regeneration, the trade-off between their effectiveness and adverse effects limits clinical application. The key issues in current growth factor therapy largely derive from initial burst pharmacokinetics, rapid clearance, and proteolytic cleavage resulting in clinical ineffectiveness
N M Shah et al.
Cell, 85(3), 331-343 (1996-05-03)
How growth factors influence the fate of multipotent progenitor cells is not well understood. Most hematopoietic growth factors act selectively as survival factors, rather than instructively as lineage determination signals. In the neural crest, neuregulin instructively promotes gliogenesis, but how
Vera Hintze et al.
Biomacromolecules, 15(8), 3083-3092 (2014-07-17)
Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and
Rick Visser et al.
Tissue engineering. Part A, 20(1-2), 34-44 (2013-07-19)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to
Ivo Dumic-Cule et al.
International orthopaedics, 38(9), 1979-1985 (2014-07-18)
Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects
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Could you please provide information on the cross-reactivity of SRP6155 with rats?
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