SML2631

IITZ-01

≥98% (HPLC)

• Synonym(e): N2-[4-(1H-Bbenzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
• Empirische Formel (Hill-System): C₂₆H₂₃FN₈O
• CAS-Nummer: 1807988-47-1
• Molekulargewicht: 482.51
• MDL-Nummer: MFCD31746904
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

IITZ-01 is a cell penetrant and potent autophagy inhibitor in numerous cancer cells including breast, lung, and colon cancer cells. It significantly elevates LC3-II and SQSTM1 protein levels in starvation-induced autophagy conditions. IITZ-01 accumulates within lysosomes causing liposomal deacidification, impairment of lysosomal maturation and inhibition of lysosomal degradation. Additionally, IITZ-01 induces apoptosis through the mitochondria-mediated pathway in TNBC cells MDA-MB-231 and MDA-MB-453, while sparing normal mammary epithelial MCF10A cell.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable