SML0898

Mps1-IN-3

≥98% (HPLC)

• Synonym(e): 1-(4-(6-(2-(Isopropylsulfonyl)phenylamino)-9H-purin-2-ylamino)-3-methoxyphenyl)piperidin-4-ol
• Empirische Formel (Hill-System): C₂₆H₃₁N₇O₄S
• CAS-Nummer: 1609584-72-6
• Molekulargewicht: 537.63
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825614
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: light yellow to dark yellow
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC1CCN(C2=CC=C(NC3=NC(NC=N4)=C4C(NC5=C(S(=O)(C(C)C)=O)C=CC=C5)=N3)C(OC)=C2)CC1
• InChI: 1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32)
• InChIKey: OFRMASLPWOMYHN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.

Anwendung

Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.

Biochem./physiol. Wirkung

Mps1 mediates phosphorylation of kinetochore scaffold 1.

Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC₅₀ value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC₅₀ value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable