Murrayafoline A, a carbazole alkaloid, is a bioactive natural compound commonly derived from plants such as Murraya euchrestifolia, Murraya kwangsiensis, Clausena excavata, Clausena dunniana, and Glycosmis stenocarpa. Current research indicates that this plant metabolite is an inhibitor and may possess diverse biological activities, including anticancer, antimalarial, cardioprotective and antifungal properties.
Anwendung
Murrayafoline A is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem./physiol. Wirkung
Murrayafoline A may be a potential chemotherapeutic agent for use in the treatment of colon cancer and may be useful in preventing the progression of vascular complications such as restenosis.
Leistungsmerkmale und Vorteile
Suitable for Biochemical and Biomedical research
Versatile and adaptable for wide variety of laboratory and research applications
Sonstige Hinweise
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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(5), 421-426 (2015-09-04)
The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF) is believed to play a central role in the etiology
Biochemical and biophysical research communications, 391(1), 915-920 (2009-12-08)
Molecular lesions in Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) occur frequently during the development of colon cancer. To identify small molecules that suppress CRT, we screened natural compounds in a cell-based assay for detection of TOPFalsh
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