M6760

Myricetin

≥96.0%, crystalline

• Synonym(e): 3,3′,4′,5,5′,7-Hexahydroxy-flavon, Cannabiscetin, Myricetol
• Empirische Formel (Hill-System): C₁₅H₁₀O₈
• CAS-Nummer: 529-44-2
• Molekulargewicht: 318.24
• Beilstein: 332331
• EG-Nummer: 208-463-2
• MDL-Nummer: MFCD00006827
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24278566
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥96.0%
• Form: crystalline
• mp (Schmelzpunkt): >300 °C (lit.)
• Löslichkeit: absolute ethanol: 10 mg/mL, clear to slightly hazy, yellow to very deep greenish-yellow
• SMILES String: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
• InChI: 1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
• InChIKey: IKMDFBPHZNJCSN-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP1A2(1544) ; mouse ... Hexa(15211) ; rat ... Il4(287287) , Tnf(24835)

Beschreibung

Anwendung

Myricetin has been used:

• to investigate its effect on end product (AGE)- bovine serum albumin mediated phosphorylation of mitogen-activated protein kinase(ERK1) [1]
• as a standard for the quantification of phenolics from noni plant extracts using high performance liquid chromatography(HPLC)[2]
• as a standard for characterization of phenolic compounds from Hibiscus sabdariffa using ultra-high performance liquid chromatography(UHPLC)[3]

Biochem./physiol. Wirkung

Myricetin is a naturally occurring flavonol with antioxidant property. It displays moderate membrane permeability and it degrades rapidly at elevated pH.[4] Myricetin is one of the major flavonoid present in edible plants and has anticarcinogenic and antimutagenic functionality.[5] It comprises of two benzene rings A and B. Ring B intercalates with nucleotide staking and inhibits bacterial DNA synthesis.[6] Myricetin elicits protective function against oxidative stress generated by tert-butylhydroperoxide (t-BHP) in diabetic rat and improves glutathione peroxidase (GPx) and xanthine oxidase (XO) enzyme activity. It also lowers the glycation of low-density lipoprotein.[1]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)