PZ0007

Azithromycin Dihydrat

≥98% (HPLC), powder, 50S ribosomal subunit formation and elongation inhibitor

• Synonym(e): N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A, CP-62993
• Empirische Formel (Hill-System): C₃₈H₇₂N₂O₁₂ · 2H₂O
• CAS-Nummer: 117772-70-0
• Molekulargewicht: 785.02
• MDL-Nummer: MFCD01862248
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823676
• NACRES: NA.77

Eigenschaften

• product name: Azithromycin Dihydrat, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: off-white
• Löslichkeit: DMSO: >20 mg/mL
• Lagertemp.: room temp
• SMILES String: O.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1
• InChIKey: SRMPHJKQVUDLQE-KUJJYQHYSA-N

Beschreibung

Anwendung

Azithromycin dihydrate has been used:

• in blocking buffer (5% bovine serum albumin) for indirect immunofluorescence
• in treating the U87 cells for cell-viability assay and flow cytometry analysis to study the Zika virus infection in glial cells
• in antibiotic co-treatment experiments, to compare its antibacterial activity with PYRRO-C3D against Streptococcus pneumoniae biofilms

Biochem./physiol. Wirkung

Azithromycin Dihydrat ist ein Makrolid-Antibiotikum, der Azalid Unterklasse. Es bindet an die 50S-Untereinheit des 70S bakterieller Ribosomen und hemmt die RNA-abhängige Protein-Synthese in Bakterienzellen. Azithromycin hat auch immunmodulierende/entzündungshemmende Eigenschaften, diese sind nützlich bei der Behandlung von zystischer Fibrose.

Azithromycin is a non-β-lactam antibody, effective against infections associated with respiratory tract, skin, tissues and genital chlamydia. It also acts against Plasmodium falciparum and P. vivax, which are multidrug resistance species that transmit malaria. Azithromycin targets the ribosome and prevents protein synthesis. It is soluble in lipids and metabolizes in liver by undergoing demethylation.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable