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Merck

O1641

Sigma-Aldrich

Ovalbumin (323-339) (chicken, Japanese quail)

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1 MG
CHF 233.00
5 MG
CHF 891.00

CHF 233.00


Voraussichtliches Versanddatum03. April 2025


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1 MG
CHF 233.00
5 MG
CHF 891.00

About This Item

UNSPSC-Code:
12352202
NACRES:
NA.26

CHF 233.00


Voraussichtliches Versanddatum03. April 2025


Bulk-Bestellung anfordern

Assay

97-100% (HPLC)

Qualitätsniveau

Form

lyophilized powder

Zusammensetzung

peptide content, 65-100%

Farbe

white

Löslichkeit

water, double-distilled: soluble

Lagertemp.

−20°C

Amino Acid Sequence

H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH

Allgemeine Beschreibung

Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes.[1]
The peptide is a major MHC class II-restricted T-cell epitope of Ovalbumin which is used for studies of immunological allergic responses such as asthma, food allergy and more..

Anwendung

Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice.[2]

Biochem./physiol. Wirkung

Ovalbumin (OVA) peptide 323-339 mediates 25–35% of T-cell response to intact OVA in isolated BALB/c mouse. OVA 323-339 has been widely used to determine the characteristics of class II major histocompatibility complex (MHC)-peptide binding and T-cell activation.[1]
With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein.[3]

Physikalische Form

Lyophilized from 0.1% aqueous TFA

Sonstige Hinweise

Lyophilized from 0.1% TFA in H2O

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Weifang Wang et al.
Frontiers in nutrition, 9, 931427-931427 (2022-08-02)
Asthma is a chronic disease, which is harmful to the health of the body and the quality of life. Supplementation of Lactobacillus can affect the immune environment of the lungs through the gut-lung axis. This study aimed to explore the
Haruyo Nakajima-Adachi et al.
Bioscience, biotechnology, and biochemistry, 76(10), 1979-1981 (2012-10-11)
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells
ORMDL3 may participate in the pathogenesis of bronchial xn-epithelialmesenchymal-1e9l transition in asthmatic mice with airway remodeling
Cheng Q, et al.
Molecular Medicine Reports, 17(1), 995-1005 (2018)
Min Liu et al.
Immunity, inflammation and disease, 11(2), e730-e730 (2023-02-18)
Asthma is a chronic respiratory disease with an increasing incidence every year. microRNAs (miRNAs) have been demonstrated to have implications for asthma. However, limited information is available regarding the effect of miR-124-3p on this disease. Therefore, this study aimed to
S Sung et al.
Journal of immunology (Baltimore, Md. : 1950), 166(2), 1261-1271 (2001-01-06)
Dendritic cells (DC) are the primary APC responsible for the capture of allergens in the airways and the shuttling of processed allergens to the draining lymph nodes where Ag presentation and T cell activation take place. The mechanism of this

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