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N6252

Sigma-Aldrich

Norharman

≥98% (TLC), crystalline, monoamine oxidase inhibitor

Synonym(e):

β-Carboline, 9H-Pyrido[3,4-b]indole

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About This Item

Empirische Formel (Hill-System):
C11H8N2
CAS-Nummer:
244-63-3
Molekulargewicht:
168.19
EG-Nummer:
205-959-0
MDL-Nummer:
MFCD00004956
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897776
NACRES:
NA.77

product name

Norharman, crystalline

Form

crystalline

Farbe

light yellow

Lagertemp.

2-8°C

SMILES String

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChIKey

AIFRHYZBTHREPW-UHFFFAOYSA-N

Angaben zum Gen

human ... IKBKB(3551)
rat ... Gabra2(29706)

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Allgemeine Beschreibung

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

Anwendung

Norharmane has been used:
  • as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
  • as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
  • as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

Biochem./physiol. Wirkung

Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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