N1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-N1,N2,N2-tris-(2-pyridinylmethyl)-1,2-ethandiamin hat bei Fluoreszenzdetektion eine hohe Empfindlichkeit für Zink-Ionen.
N1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-N1,N2,N2-tris(2-pyridinylmethyl)-1,2-ethanediamine has a high sensitivity for zinc ions. Using fluorescent detection, a linear responsive is observed for Zn2+ concentrations in the range of 1-10 μM. It has good selectivity for Zn2+ in the presence of competing metal ions, such as Ca2+, Mg2+, Fe2+, Fe3+, and Mn2+, and has been used in vivo to determine Zn2+ concentration in pancreatic β cells and zebra fish larvae.
Journal of fluorescence, 30(6), 1553-1565 (2020-09-19)
Zinc is essential for growth and development of all living organisms, especially human being. Deficiency of micronutrients like zinc and iron has been linked to the manifestation of hidden hunger. Therefore, it is imperative that development of some rapid screening
Macrophages use diverse strategies to restrict intracellular pathogens, including either depriving the bacteria of (micro)nutrients such as transition metals or intoxicating them via metal accumulation. Little is known about the chemical warfare between Mycobacterium marinum, a close relative of Mycobacterium
International journal of nanomedicine, 15, 1457-1468 (2020-03-19)
Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure. However, possible anticancer mechanisms of epigenetic dysregulation induced by low doses of nZnO are
Professional phagocytes have developed an extensive repertoire of autonomous immunity strategies to ensure killing of bacteria. Besides phagosome acidification and the generation of reactive oxygen species, deprivation of nutrients and the lumenal accumulation of toxic metals are essential to kill
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