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L5011

Sigma-Aldrich

Leukotriene D4

~50 μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6), ≥97%

Synonym(e):

LTD4

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About This Item

Empirische Formel (Hill-System):
C25H40N2O6S
CAS-Nummer:
73836-78-9
Molekulargewicht:
496.66
MDL-Nummer:
MFCD00036839
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24896383
NACRES:
NA.77

Qualitätsniveau

200

Assay

≥97%

Konzentration

~50 μg/mL (in methanol/ammonium acetate buffer, 70:30, pH 5.6)

Versandbedingung

dry ice

Lagertemp.

−70°C

SMILES String

CCCCC\C=C\C/C=C\C=C\C=C\[C@@H](SC[C@@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O

InChI

1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6+,10-9-,12-11+,16-13+/t20-,21+,22-/m1/s1

InChIKey

YEESKJGWJFYOOK-GKWRKXFUSA-N

Biochem./physiol. Wirkung

Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.

Leistungsmerkmale und Vorteile

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Verpackung

Packaged under argon.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 3

Flammpunkt (°F)

49.5 °F

Flammpunkt (°C)

9.7 °C

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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Weijie Guan et al.
The Journal of allergy and clinical immunology, 131(2), 332-338 (2012-10-09)
Both leukotriene D(4) (LTD(4)) and methacholine bronchial provocation tests are measurements of airway responsiveness; however, their correlation and distinction remain unexplored. We sought to compare the 2 tests and classify leukotriene-responsiveness subtypes in asthmatic patients. In this randomized cross-over study
A Sjölander et al.
The Journal of biological chemistry, 265(34), 20976-20981 (1990-12-05)
Leukotrienes are recognized as important mediators of the inflammatory process. Recently, increasing attention has been paid to the role of noninflammatory cells in the regulation of the inflammatory process. To further increase our knowledge of this matter we have, in
Celine N Parmentier et al.
The Journal of allergy and clinical immunology, 129(4), 1136-1142 (2012-03-07)
Allergic asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness associated with T(H)2 cell-mediated inflammation. Cysteinyl leukotrienes (CysLTs) are potent lipid mediators involved in bronchoconstriction, mucus secretion, and cell trafficking in asthmatic patients. Recent data have implicated CysLTs in
Hisako Matsumoto et al.
Cytokine, 57(1), 19-24 (2011-11-15)
Physiological mechanisms associated with interleukin-13 (IL-13), a key cytokine in asthma, in intracellular Ca(2+) signaling in airway smooth muscle cells (ASMCs) remain unclear. The aim of this study was to assess effects of IL-13 on Ca(2+) oscillations in response to
Pontus K A Forsell et al.
Lipids, 47(8), 781-791 (2012-06-12)
Human 15-lipoxygenase-1 (15-LO-1) can metabolize arachidonic acid (ARA) into pro-inflammatory mediators such as the eoxins, 15-hydroperoxyeicosatetraenoic acid (HPETE), and 15-hydroxyeicosatetraenoyl-phosphatidylethanolamine. We have in this study investigated the formation of various lipid hydroperoxide by either purified 15-LO-1 or in the Hodgkin
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