H6036

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

powder, ≥98% (HPLC)

• Synonym(e): PPT
• Empirische Formel (Hill-System): C₂₄H₂₂N₂O₃
• CAS-Nummer: 263717-53-9
• Molekulargewicht: 386.44
• MDL-Nummer: MFCD03453628
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24278470
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: soluble 20 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4
• InChI: 1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
• InChIKey: IOTXSIGGFRQYKW-UHFFFAOYSA-N
• Angaben zum Gen: human ... ESR1(2099)

Beschreibung

Allgemeine Beschreibung

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Anwendung

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole has been used to cultivate differentiated adipocytes. It is also used in drug treatments and radioimmunoassay (RIA).

Biochem./physiol. Wirkung

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.

PPT is a specific estrogen receptor α (ERα) agonist.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)