W1520

WAY-200070

≥98% (HPLC)

• Synonym(e): 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol, 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
• Empirische Formel (Hill-System): C₁₃H₈BrNO₃
• CAS-Nummer: 440122-66-7
• Molekulargewicht: 306.11
• NACRES: NA.77
• PubChem Substance ID: 329830426
• UNSPSC Code: 51111800
• MDL number: MFCD16618385
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥20 mg/mL
• originator: Wyeth
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2
• InChI: 1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H
• InChI key: BAAILVWEAXFTSF-UHFFFAOYSA-N

Beschreibung

General description

WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Application

WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response.[1][2] WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.[3]

Biochem/physiol Actions

Potent, selective estrogen receptor-beta (ER-β) agonist (IC₅₀ 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable