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Merck

E007626

Sigma-Aldrich

Phenylmethansulfonylfluorid

Synonym(e):

α-Toluol-sulfonylfluorid, Benzylsulfonylfluorid, DFP-Substitute, PMSF

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About This Item

Empirische Formel (Hill-System):
C7H7FO2S
CAS-Nummer:
Molekulargewicht:
174.19
Beilstein:
2088311
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202

SMILES String

FS(=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChIKey

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

PMSF was shown to inhibit activity of cathepsin-G thereby preventing the neutrophil-induced lysis of neuroblastoma tumor cells in in vitro studies.

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Analysenzertifikate (COA)

Lot/Batch Number

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E Barker et al.
Cancer research, 53(2), 362-367 (1993-01-15)
Neutrophils mediate the lysis of human neuroblastoma cells coated with human/mouse chimeric anti-GD2 ganglioside antibody ch14.18. This study examined the mechanism(s) by which this occurs. Neutrophil degranulation was found to be a required step for lysis, since release of granular
Lise Boussemart et al.
Nature, 513(7516), 105-109 (2014-08-01)
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K-AKT-mTOR, pathway (which is ERK independent)
Z Xiong et al.
Stem cell research, 12(2), 387-399 (2014-01-01)
An essential step for therapeutic and research applications of stem cells is their ability to differentiate into specific cell types. Neuronal cells are of great interest for medical treatment of neurodegenerative diseases and traumatic injuries of central nervous system (CNS)
Sylvie Bannwarth et al.
Brain : a journal of neurology, 137(Pt 8), 2329-2345 (2014-06-18)
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare. We report a large family with a late-onset phenotype including motor neuron disease, cognitive decline resembling frontotemporal
Tomer Shpilka et al.
The EMBO journal, 34(16), 2117-2131 (2015-07-15)
Autophagy is a major catabolic process responsible for the delivery of proteins and organelles to the lysosome/vacuole for degradation. Malfunction of this pathway has been implicated in numerous pathological conditions. Different organelles have been found to contribute to the formation

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