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D2438

Sigma-Aldrich

Dimethylsulfoxid

Dimethyl sulfoxide

sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Synonym(e):

DMSO, Methylsulfoxid

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50 ML
CHF 200.00
5 X 10 ML
CHF 209.00

CHF 200.00

Voraussichtliches Versanddatum28. März 2025

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50 ML
CHF 200.00
5 X 10 ML
CHF 209.00

About This Item

Lineare Formel:
(CH3)2SO
CAS-Nummer:
67-68-5
Molekulargewicht:
78.13
Beilstein:
506008
EG-Nummer:
200-664-3
MDL-Nummer:
MFCD00002089
UNSPSC-Code:
12191502
PubChem Substanz-ID:
24893688
NACRES:
NA.75
Qualität:
BioPerformance Certified
Methode(n):
cell culture | hybridoma: suitable
cryopreservation: suitable
bp:
189 °C (lit.)
Dampfdruck:
0.42 mmHg ( 20 °C)

CHF 200.00

Voraussichtliches Versanddatum28. März 2025

Qualität

BioPerformance Certified

Qualitätsniveau

400

Agentur

USP XXIV
meets EP testing specifications
meets USP testing specifications

Dampfdichte

2.7 (vs air)

Dampfdruck

0.42 mmHg ( 20 °C)

Sterilität

sterile-filtered

Form

liquid

Selbstzündungstemp.

573 °F

Expl.-Gr.

42 %, 63 °F

Methode(n)

cell culture | hybridoma: suitable
cryopreservation: suitable

Verunreinigungen

≤0.1% water

Farbe

colorless

Brechungsindex

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp (Schmelzpunkt)

16-19 °C (lit.)

Löslichkeit

H2O: miscible (completely)

Dichte

1.10 g/mL (lit.)

SMILES String

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChIKey

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Dimethylsulfoxid (DMSO) ist ein aprotisches Lösungsmittel. Therapeutische und toxische Moleküle, die nicht wasserlöslich sind, sind oft in DMSO löslich. Flüssiger Stickstoff in Kombination mit einem Gefrierschutzmittel wie DMSO ist ein häufig angewendetes Verfahren zur Konservierung von Zellen. DMSO wird zur Herstellung von Stammlösungen verschiedener Moleküle und auch als Kontrolle für diese Moleküle verwendet. Es wird in Zellmigrationsassays zum Lösen von Zellen nach der Migration verwendet. BPC-getestetes DMSO erfüllt auch die Anforderungen für Anwendungen in der Biotechnologie und Gewebezüchtung.

Anwendung

Dimethylsulfoxid wurde als Vehikelkontrolle zum Kultivieren und Einleiten der Aktivität von hepatischen Sternzellen (HSC) in vivo verwendet.[1][1] Es wurde auch zum Herstellen einer Stammlösung zum Untersuchen der Zytotoxizität von Ferulasäure auf NP-Zellen (Nucleus pulposus) eingesetzt.[2]

Leistungsmerkmale und Vorteile

Gebrauchsfertiges, sterilfiltriertes Produkt, anwendungsfreundlich in Braunglasflaschen mit Schraubkappe mit Septum abgefüllt. Erfüllt die USP- und EP-Testanforderungen

Vorsicht

Unterkühlt leicht und schmilzt langsam bei Raumtemperatur. Das verfestigte Produkt kann durch Erwärmen auf Raumtemperatur wieder verflüssigt werden, ohne dabei geschädigt zu werden.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

188.6 °F - closed cup

Flammpunkt (°C)

87 °C - closed cup

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
RNBM1118
RNBM0113
RNBM0642
RNBM0358
RNBL9232

Die passende Version wird nicht angezeigt?

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Suche nach COA

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Die Dokumentenbibliothek aufrufen

A Oguro-Ando et al.
Molecular psychiatry, 20(9), 1069-1078 (2014-10-15)
Rare maternally inherited duplications at 15q11-13 are observed in ~1% of individuals with an autism spectrum disorder (ASD), making it among the most common causes of ASD. 15q11-13 comprises a complex region, and as this copy number variation encompasses many
Caroline Godfrey et al.
Human molecular genetics, 24(15), 4225-4237 (2015-05-03)
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in muscle
C F Brayton
The Cornell veterinarian, 76(1), 61-90 (1986-01-01)
Dimethyl sulfoxide (DMSO) is a very simple compound that has stimulated much controversy in the scientific and popular literature. Fig. 1 It is an aprotic solvent. Therapeutic and toxic agents that are not soluble in water are often soluble in
Björn Zörner et al.
Brain : a journal of neurology, 137(Pt 6), 1716-1732 (2014-04-17)
Anatomical plasticity such as fibre growth and the formation of new connections in the cortex and spinal cord is one known mechanism mediating functional recovery after damage to the central nervous system. Little is known about anatomical plasticity in the
Mulmudi Hemant Kumar et al.
Advanced materials (Deerfield Beach, Fla.), 26(41), 7122-7127 (2014-09-13)
Lead free perovskite solar cells based on a CsSnI3 light absorber with a spectral response from 950 nm is demonstrated. The high photocurrents noted in the system are a consequence of SnF2 addition which reduces defect concentrations and hence the
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Artikel

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

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Questions

1–10 of 15 Questions  

  1. Hi, what is the difference between DMSO product# D2438 and D2650? What is Hybri-Max vs. BioPerformance certified and meets USP testing specification?

    1 answer

    1. Both D2438 and D2650 are suitable for cell culture. The D2650 is part of the Hybri-Max™ product line. Hybri-Max products have been tested for use in hybridoma creation and culture. The D2438 is part of the BioPerformance Certified group of products. These products are tested and optimized for use in biological applications. For this product and a number of others, this includes testing to meet USP and EP guidelines. Please see the links below to review a sample Certificate of Analysis for each item.
      D2650
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation
      D2438
      https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation

      Helpful?

  2. Purity grade of the product ?

    1 answer

    1. The purity of this product is listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate:
      https://www.sigmaaldrich.com/product/sigma/d2438#product-documentation

      Helpful?

  3. El DMSO es sensible a la luz, hay que tomar alguna precaución al respecto?

    1 answer

    1. This product is packaged in amber glass and is protected from light. The 10 mL size is packaged in a sealed ampule. Once opened, any content that is not used should also be stored in amber glass. For long term storage, the material may also be stored under inert gas to preserve the shelf life. Note that this material has a tendency to absorb water. Containers should be tightly sealed.

      Helpful?

  4. what are the storing conditions?

    1 answer

    1. This product is stored at room temperature. Store in a well-ventilated place. Keep cool. Please see the Material Safety Data Sheet for more information: https://www.sigmaaldrich.com/sds/sigma/d2438.

      Helpful?

  5. What is the difference between products D2438 and D8418?

    1 answer

    1. The D2438 is a BioPerformance Certified grade product suitable for cell culture, hybridoma creation, and cryopreservation. It is intended for research use only but does meet USP and EP testing requirements. The D8418 is a molecular biology-grade product suitable for DNA sequencing, PCR, and transfection. It has been tested for RNAse and DNAse. The products can be selected based on the application.

      Please view the sample Certificate of Analysis for each product to see the testing specifications associated with that item:
      https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/PDF734068.pdf
      https://www.sigmaaldrich.com/coa/SIGMA/D2438/RNBL8837

      Helpful?

  6. What is the basis for the endotoxin specification for Dimethyl sulfoxide (DMSO)?

    1 answer

    1. The industry standard for 'endotoxin free' is less than 1 EU/mL.

      Helpful?

  7. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    1 answer

    1. DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

      Helpful?

  8. What concentration of DMSO do I use in a cell freezing media?

    1 answer

    1. DMSO is usually used at 1-10%, depending on the cell line.  For the cell freezing media that we offer, it is used at 8.7% concentration.

      Helpful?

  9. What is the molarity of DMSO?

    1 answer

    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  10. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer

    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

1–10 of 15 Questions  

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