C8897
Kollagen aus Rattenschwanz
Bornstein and Traub Type I (Sigma Type VII), powder
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About This Item
Empfohlene Produkte
Biologische Quelle
rat tail
Form
powder
Methode(n)
cell culture | mammalian: suitable
Löslichkeit
aqueous acid: soluble
UniProt-Hinterlegungsnummer
Lagertemp.
2-8°C
Angaben zum Gen
rat ... Col1a1(29393)
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Anwendung
This product is intended to produce thin layer coatings on tissue culture plates to facilitate attachment of anchorage-dependent cells, recommended for use at 6-10 μg/cm2. It is NOT intended for production of 3-D gels. Type I collagen is often used in cell culture as an attachment substratum with myoblasts, spinal ganglia, hepatocytes, embryonic lung, heart explants, fibroblasts, endothelial cells, and islet cells have all been cultured successfully on films or gels of type I collagen. Collagen type I may also be used in research of Idiopathic pulmonary fibrosis (IPF), studies on the effect of ER stress IPF on lung fibroblasts. Collagen in acidic solution can produce three dimensional scaffolding with use in bioengineering and cell culture applications.
Biochem./physiol. Wirkung
Type I collagen is a component of skin, bone, tendon, and other fibrous connective tissues.
Komponenten
All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type I collagen differs from other collagens by its low lysine hydroxylation and low carbohydrate composition.
Angaben zur Herstellung
This product was prepared by a modification of the extraction method of Bornstein, M.B., Lab. Invest., 7, 134 (1958). It is an acid soluble collagen. It dissolves in water with acetic acid added to pH 3.0 at 5 mg/mL, yielding an opalescent, colorless solution.
Sonstige Hinweise
Kollagen wird in eine Reihe an strukturell und genetisch verschiedenen Typen unterteilt. Wir nutzen die Nomenklatur, die von Bornstein und Traub vorgeschlagen wurde. Verwechseln Sie die Typenbezeichnungen von Sigma nicht mit anerkannten Typenklassifizierungen von Kollagen.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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