A3145

Apigenin

≥97% (TLC), from parsley, powder

• Synonym(e): 4′,5,7-Trihydroxy-flavon, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron
• Empirische Formel (Hill-System): C₁₅H₁₀O₅
• CAS-Nummer: 520-36-5
• Molekulargewicht: 270.24
• Beilstein: 262620
• EG-Nummer: 208-292-3
• MDL-Nummer: MFCD00006831
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278212

Eigenschaften

• Biologische Quelle: parsley
• Assay: ≥97% (TLC)
• Form: powder
• Farbe: yellow
• mp (Schmelzpunkt): >300 °C (lit.)
• Löslichkeit: DMSO: 27 mg/mL; 1 M KOH: 50 mg/mL
• Lagertemp.: −20°C
• SMILES String: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChIKey: KZNIFHPLKGYRTM-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADORA3(140) , CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , ESR1(2099) , ESR2(2100) , GSK3A(2931) ; mouse ... Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Il4(287287) , Tnf(24835)

Beschreibung

Biochem./physiol. Wirkung

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves