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82934

Sigma-Aldrich

7-Hydroxycitronellal

Odorant used in allergy studies

Synonym(e):

7-Hydroxy-3,7-dimethyl-octanal, Citronellalhydrat

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About This Item

Empirische Formel (Hill-System):
C10H20O2
CAS-Nummer:
107-75-5
Molekulargewicht:
172.26
EG-Nummer:
203-518-7
MDL-Nummer:
MFCD00014681
UNSPSC-Code:
12352200
PubChem Substanz-ID:
57652938
NACRES:
NA.52

Qualität

Molecular Biology
for molecular biology

Assay

≥95.0% (GC)

Form

powder

Dichte

0.92 g/mL at 20 °C (lit.)

Lagertemp.

room temp

SMILES String

[H]C(CC(C)CCCC(O)(C)C)=O

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

InChIKey

WPFVBOQKRVRMJB-UHFFFAOYSA-N

Allgemeine Beschreibung

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

Anwendung

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SDBB2357
SDBB0781
STBL1364
STBL1767
BCCH9854

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Die Dokumentenbibliothek aufrufen

Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
R A Ford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(11-12), 921-926 (1988-11-01)
Hydroxycitronellal, an important ingredient in fragrances, was studied for its sensitizing potential in human skin. Fifteen human maximization tests were conducted with hydroxycitronellal obtained from four different sources at induction concentrations from 5 to 12%. No reactions were induced at
M Krasteva et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 26(5), 563-570 (1996-05-01)
The need to develop predictive tests which could identify potential allergens has been recognized for many years. There is as yet no accepted in vitro method for the assessment of contact sensitizers. We have tested the ability of a range
S Sieben et al.
Toxicology and applied pharmacology, 172(3), 172-178 (2001-04-21)
Fragrances are worldwide a major cause of allergic contact dermatitis (ACD), a delayed-type hypersensitivity reaction mediated by T lymphocytes. We investigated T cell responses to fragrances using peripheral blood mononuclear cells (PBMC) and T cells from skin lesions of fragrance-allergic
Fabien Merckel et al.
Chemical research in toxicology, 23(9), 1433-1441 (2010-08-28)
In chemico methods, based on the assessment of hapten reactivity toward peptides, have been proposed as alternative methods for the assessment of the skin sensitizing potential of chemicals. However, even if these approaches seem very promising, a major drawback inherent
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