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Sigma-Aldrich

9-(2,2-Dicyanovinyl)julolidin

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

Synonym(e):

9-Julolidinylmethylenmalononitril, DCVJ

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About This Item

Empirische Formel (Hill-System):
C16H15N3
CAS-Nummer:
58293-56-4
Molekulargewicht:
249.31
Beilstein:
413882
MDL-Nummer:
MFCD01747392
UNSPSC-Code:
12352108
PubChem Substanz-ID:
57652412
NACRES:
NA.32

Produktlinie

BioReagent

Qualitätsniveau

100

Assay

≥97.0% (HPLC)

Form

crystals

Löslichkeit

DMSO: soluble
chloroform: soluble

Fluoreszenz

λex 433 nm; λem 500 nm in 50 mM Tris pH 8.0; 40% glycerol

Eignung

suitable for fluorescence

SMILES String

N#C\C(=C/c1cc2CCCN3CCCc(c1)c23)C#N

InChI

1S/C16H15N3/c17-10-13(11-18)7-12-8-14-3-1-5-19-6-2-4-15(9-12)16(14)19/h7-9H,1-6H2

InChIKey

LROAUBRDKLVBCP-UHFFFAOYSA-N

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sonstige Hinweise

Fluoreszenz-Sonde für die Bindung an Proteine etc., Quantenausbeute steigt durch die Abnahme der Rotationsfreiheit; Absorption bei ~450 nm, Emission bei 480-505 nm (lösungsmittelabhängig)

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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A Bhattacharyya et al.
Indian journal of biochemistry & biophysics, 32(6), 442-446 (1995-12-01)
Di(cyano vinyl)julolidine (DCVJ) is a fluorescent probe which has been used to monitor the local mobility of its binding sites on proteins. It shows a concentration dependence of its emission spectrum in water. At higher DCVJ concentrations, a longer wavelength
Andrea Hawe et al.
Pharmaceutical research, 27(2), 314-326 (2009-12-31)
The aim was to evaluate fluorescent molecular rotors (DCVJ and CCVJ), which are mainly sensitive to viscosity, for the characterization of polysorbate-containing IgG formulations and compare them to the polarity-sensitive dyes ANS, Bis-ANS and Nile Red. IgG formulations with polysorbate
M A Haidekker et al.
American journal of physiology. Heart and circulatory physiology, 278(4), H1401-H1406 (2000-04-06)
Fluid shear stress (FSS) has been shown to be an ubiquitous stimulator of mammalian cell metabolism. Although many of the intracellular signal transduction pathways have been characterized, the primary mechanoreceptor for FSS remains unknown. One hypothesis is that the cytoplasmic
Christian Lubich et al.
Pharmaceutical research, 32(9), 2863-2876 (2015-03-20)
Sub-visible particles were shown to facilitate unwanted immunogenicity of protein therapeutics. To understand the root cause of this phenomenon, a comprehensive analysis of these particles is required. We aimed at establishing a flow-cytometry-based technology to analyze the amount, size distribution
Markus J Schmidt et al.
Journal of biological engineering, 11, 24-24 (2017-08-09)
The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a previously reported photoisomeric behavior may contribute to the measured fluorescence intensity
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