Y0001933

Tacrolimus für die Systemeignung

European Pharmacopoeia (EP) Reference Standard

• Synonym(e): FK-506 Monohydrat, Tacrolimus
• Empirische Formel (Hill-System): C₄₄H₆₉NO₁₂ · H₂O
• CAS-Nummer: 109581-93-3
• Molekulargewicht: 822.03
• MDL-Nummer: MFCD11045918
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: tacrolimus
• Hersteller/Markenname: EDQM
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: O.CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC
• InChI: 1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
• InChIKey: NWJQLQGQZSIBAF-MLAUYUEBSA-N
• Angaben zum Gen: human ... FKBP1A(2280)

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Tacrolimus for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

FK-506 ist ein starkes Immunsuppressivum, wirkt neuroprotektiv und neuroregenerativ und blockiert in vitro die Proliferation von T-Zellen. FK-506 unterbricht die Calcineurin-vermittelte Signalübertragung in T-Lymphozyten und interagiert mit dem FK-506-bindenden Protein 12 (FKBP12).

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P330 + P331 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable