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Glycidamid

analytical standard

Synonym(e):

Oxirancarboxamid

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About This Item

Empirische Formel (Hill-System):
C3H5NO2
CAS-Nummer:
5694-00-8
Molekulargewicht:
87.08
Beilstein:
227 163 2
EG-Nummer:
227-163-2
MDL-Nummer:
MFCD00468053
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329747975
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥95% (qNMR)

Haltbarkeit

limited shelf life, expiry date on the label

Anwendung(en)

environmental

Format

neat

Lagertemp.

2-8°C

SMILES String

NC(=O)C1CO1

InChI

1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)

InChIKey

FMAZQSYXRGRESX-UHFFFAOYSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.

Anwendung

Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.

Sonstige Hinweise

Im Sommer 2008 haben Wissenschaftler an der Technischen Universität München, neben Acrylamid, Glycidamid in Kartoffelchips nachgewiesen. Glycidamid ist ein Stoffwechselprodukt von Acrylamid.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Analysenzertifikate (COA)

Lot/Batch Number
BCCK2598
BCCC1244
BCCC1105
BCCB2285
BCBW5033

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Glyceringlycid 96%

Sigma-Aldrich

G5809

Glyceringlycid

Talita Duarte-Salles et al.
Environmental health perspectives, 121(3), 374-379 (2012-12-04)
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects
Hitesh V Motwani et al.
Journal of chromatography. A, 1218(28), 4389-4394 (2011-06-10)
Glycidamide (GA) is the epoxy metabolite of acrylamide (AA). A sensitive analytical method for quantitative measurement of GA from in vitro metabolism studies is useful in several contexts, e.g. in studies of enzyme kinetics in different species and factors influencing
Nico Watzek et al.
Chemical research in toxicology, 25(2), 381-390 (2012-01-04)
Acrylamide (AA) is formed during the heating of food and is classified as a genotoxic carcinogen. The margin of exposure (MOE), representing the distance between the bench mark dose associated with 10% tumor incidence in rats and the estimated average
Hitesh V Motwani et al.
Scientific reports, 7(1), 17560-17560 (2017-12-16)
When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo dose, i.e. area under concentration-time
Marie Pedersen et al.
Environmental health perspectives, 120(12), 1739-1745 (2012-10-25)
Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. We examined the associations between prenatal exposure to acrylamide and birth outcomes in
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