475886

N^G-Monomethyl-L-arginine, Monoacetate Salt

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.

• Synonym(e): N^G-Monomethyl-L-arginine, Monoacetate Salt, N ^ω-Me-L-Arg, N ^G-Me-L-Arg, AcOH, L-NMMA, N^ω-Me-L-Arg, N^G-Me-L-Arg, AcOH, L-NMMA
• Empirische Formel (Hill-System): C₇H₁₆N₄O₂ · xC₂H₄O₂
• CAS-Nummer: 53308-83-1
• Molekulargewicht: 188.23 (free base basis)
• MDL-Nummer: MFCD00069311
• UNSPSC-Code: 12352209
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99% (HPLC); ≥99% (TLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: white
• Löslichkeit: water: 50 mg/mL; methanol: soluble
• Versandbedingung: ambient
• Lagertemp.: 10-30°C
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• InChIKey: IKPNWIGTWUZCKM-JEDNCBNOSA-N

Beschreibung

Allgemeine Beschreibung

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS; K_i = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

L-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (K_i = 650 nM for nNOS; K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
eNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.

Sonstige Hinweise

Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys.320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun.158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA85, 8664.
Hibbs, J.B., et al. 1987. Science237, 473.
Palmer, R.M.J., et al. 1987. Nature327, 524.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable