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05-364

Sigma-Aldrich

Anti-Cdk5 Antibody, clone DC17

clone DC17, Upstate®, from mouse

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

DC17, monoclonal

Speziesreaktivität

mouse, human, Drosophila, rat

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

fruit fly ... Cdk5(36727)
human ... CDK5(1020)
mouse ... Cdk5(12568)
rat ... Cdk5(140908)

Spezifität

cdk5

Immunogen

Recombinant human cdk5

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
Zellzyklus, DNA-Replikation & -Reparatur
Anti-Cdk5 Antibody, clone DC17 is a high quality Mouse Monoclonal Antibody for the detection of Cdk5 & has been validated in IP, WB, ICC.

Qualität

routinely evaluated by immunoblot on RIPA lysate from non-stimulated human A431 cells, mouse Wehi cells or rat PC12 cells

Zielbeschreibung

33kDa

Physikalische Form

Protein G Chromatography
0.1M Tris-glycine pH 7.4, 0.15M NaCl, containing 0.05% sodium azide
Format: Purified

Lagerung und Haltbarkeit

2 years at -20°C

Hinweis zur Analyse

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for minigels.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

K Sobue et al.
The Journal of biological chemistry, 275(22), 16673-16680 (2000-04-06)
Neuronal Cdc2-like protein kinase (NCLK), a approximately 58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901). The biochemical nature
Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Yin, DM; Huang, YH; Zhu, YB; Wang, Y
The Journal of Neuroscience null
H Lin et al.
Cell death and differentiation, 14(3), 607-615 (2006-08-26)
Although Abl functions in mature neurons, work to date has not addressed Abl's role on Cdk5 in neurodegeneration. We found that beta-amyloid (Abeta42) initiated Abl kinase activity and that blockade of Abl kinase rescued both Drosophila and mammalian neuronal cells
The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.
Yi He,Hui-Li Li,Wei-Yan Xie,Chun-Zhang Yang,Albert Cheung Hoi Yu,Yun Wang
Glia null
S R Floyd et al.
The Journal of biological chemistry, 276(11), 8104-8110 (2000-12-13)
Amphiphysin 1 is a phosphoprotein expressed at high levels in neurons, where it participates in synaptic vesicle endocytosis and neurite outgrowth. It is a substrate for cyclin-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase family, which has

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