T-076

L-Thyroxine-¹³C₆ solution

100 μg/mL in methanol with 0.1N NH₃, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): ¹³C₆C₉H₁₁I₄NO₄
• CAS-Nummer: 720710-30-5
• Molekulargewicht: 782.83
• EG-Nummer: 200-659-6
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Form: liquid
• Leistungsmerkmale: (Snap-N-Spike^®)
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 100 μg/mL in methanol with 0.1N NH₃
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: I[13C]1=[13C]([13C](I)=[13CH][13C](C[C@@H](C(O)=O)N)=[13CH]1)OC2=CC(I)=C(O)C(I)=C2
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1/i1+1,2+1,6+1,10+1,11+1,14+1
• InChIKey: XUIIKFGFIJCVMT-PDHVKVOFSA-N

Beschreibung

Allgemeine Beschreibung

This internal standard and Certified Spiking Solution^® is suitable for quantitation of free and total T₄ serum levels by LC-MS/MS for determination of hyper- or hypothyroidism and monitoring treatment with synthetic thyroid hormones.

L-Thyroxine-¹³C₆ is an isotopically labeled form of the tyrosine-based thyroid hormone, thyroxine (T₄). Thyroxine is secreted by the thyroid gland and is involved in different biological processes, such as growth, neurodevelopment, carbohydrate & oxygen metabolism, and protein synthesis

Anwendung

The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:

• Combination of hollow fiber-liquid-phase microextraction (HF-LPME) based sample preparation and liquid chromatography-tandem mass spectrometric (LC-MS/MS) determination of total thyroxine in serum samples
• Development of an LC-MS/MS method for the multi-residue analysis of melatonin, cortisol, triiodothyronine, thyroxine, and testosterone in rat serum samples following their dual liquid-liquid extraction
• Simultaneous determination of thyroxine by an isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method from human serum samples
• Estimation of thyroxine (T₄) and triiodothyronine (T₃) in rat cardiac tissue samples by a high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method following their derivatization
• Establishing and validating an LC-MS/MS-based method for the quantification of endogenous thyroid hormones, T₄ and two of its T₃ isomers, in tissue samples obtained from lamprey, following the enzymatic digestion and protein precipitation of the samples

Leistungsmerkmale und Vorteile

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225,H301 + H311 + H331,H370
• P-Sätze: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes,Central nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 49.5 °F
• Flammpunkt (°C): 9.7 °C