331856

(2S,3R)-(+)-N-Z-6-Oxo-2,3-diphenylmorpholin

99%

• Synonym(e): Benzyl-(2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholincarboxylat
• Empirische Formel (Hill-System): C₂₄H₂₁NO₄
• CAS-Nummer: 105228-46-4
• Molekulargewicht: 387.43
• MDL-Nummer: MFCD00074956
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24860003
• NACRES: NA.22

Eigenschaften

• Assay: 99%
• Optische Aktivität: [α]25/D +66°, c = 5.5 in methylene chloride
• mp (Schmelzpunkt): 205-207 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: O=C1CN([C@@H]([C@@H](O1)c2ccccc2)c3ccccc3)C(=O)OCc4ccccc4
• InChI: 1S/C24H21NO4/c26-21-16-25(24(27)28-17-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)23(29-21)20-14-8-3-9-15-20/h1-15,22-23H,16-17H2/t22-,23+/m1/s1
• InChIKey: HECRUWTZAMPQOS-PKTZIBPZSA-N

Beschreibung

Anwendung

(2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylmorpholine can be used as a starting material for the synthesis of:

• α-Amino-β-silyloxy-ester, a key intermediate for the preparation of antimalarial drug quinine and its analogs.
• R, R-Formylglycine dimethylacetal, a key intermediate for the preparation of tuberculostatic compound capreomycin IB.
• 2R,5R,6S-2-(Methoxycarbonylmethyl)-5,6-diphenylmorpholine hydrochloride, a key intermediate for the preparation of an antibiotic (+)-negamycin.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves