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Dokumente

284572

Sigma-Aldrich

4-Aminobenzamid

98%

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About This Item

Lineare Formel:
H2NC6H4CONH2
CAS-Nummer:
2835-68-9
Molekulargewicht:
136.15
EG-Nummer:
220-612-3
MDL-Nummer:
MFCD00007999
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24857167
NACRES:
NA.22

Assay

98%

Form

solid

mp (Schmelzpunkt)

181-183 °C (lit.)

SMILES String

NC(=O)c1ccc(N)cc1

InChI

1S/C7H8N2O/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H2,9,10)

InChIKey

QIKYZXDTTPVVAC-UHFFFAOYSA-N

Verwandte Kategorien

Anwendung

4-Aminobenzamide was used as a poly(ADP-ribose)polymerase (PADPRP) inhhibitor to study the death of target cells by cytotoxic effector cells using the nuclear enzyme poly(ADP-ribose)polymerase (PADPRP).

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319,H335

Gefahreneinstufungen

Eye Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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P Burgman et al.
Radiation research, 116(3), 406-415 (1988-12-01)
The purpose of this study was to investigate a possible involvement of poly(ADP-ribosyl)ation reactions in hyperthermic cell killing and hyperthermic DNA strand-break induction and repair in HeLa S3 cells. The inhibitors of poly(ADP-ribose) polymerase, 3-aminobenzamide (3AB) and 4-aminobenzamide (4AB), were
Jamie Lajiness et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 5(3), 216-226 (2009-05-16)
Imidazole and pyrrole-containing polyamides belong to an important class of compounds that can be designed to target specific DNA sequences, and they are potentially useful in applications of controlling gene expression. The extent of polyamide curvature is an important consideration
D Monti et al.
Biochemical and biophysical research communications, 199(2), 525-530 (1994-03-15)
The death of target cells by cytotoxic effector cells is a relevant biological phenomenon, where cells are activated and a very quick apoptotic program occurs. In order to test the hypothesis that the nuclear enzyme poly(ADP-ribose)polymerase (PADPRP) plays a role
E Ben-Hur et al.
Radiation research, 97(3), 546-555 (1984-03-01)
Postirradiation incubation of V79 Chinese hamster cells with inhibitors of poly(ADP-ribose) synthesis was found to potentiate the killing of cells by X rays. Potentiation increased with incubation time and with concentration of the inhibitor. Preirradiation incubation had only a small
R Laffranchi et al.
Experimental cell research, 237(1), 217-222 (1998-01-07)
Interferon-gamma is among the cytokines which have been implicated as effector molecules of beta-cell destruction in autoimmune diabetes. Its mechanism of action is, however, largely unknown. In the present study rat pancreatic beta-cells, INS-1, were incubated with rat interferon-gamma (rIRN-gamma)
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