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Merck
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Principaux documents

JN0007

Sigma-Aldrich

Sabeluzole

≥98% (HPLC)

Synonyme(s) :

(RS)-1-(4-(Benzo[d]thiazol-2-yl(methyl)amino)piperidin-1-yl)-3-(4-fluorophenoxy)propan-2-ol, (RS)-1-[4-[1,3-Benzothiazol-2-yl(methyl)amino]-1-piperidyl]-3-(4-fluorophenoxy)propan-2-ol, (RS)-4-(2-Benzothiazolylmethylamino)-a-[(4-fluorophenoxy)methyl]-1-piperidineethanol, Arbetuzole, R 58 735, R 58,735, R 58735, R-58,735, R058735, R58 735, R58735

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About This Item

Formule empirique (notation de Hill):
C22H26FN3O2S
Numéro CAS:
104383-17-7
Poids moléculaire :
415.52
Numéro MDL:
MFCD00865935
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 2 mg/mL, clear

Température de stockage

room temp

Chaîne SMILES 

Fc1ccc(cc1)OCC(O)CN2CCC(CC2)N(C)c3[s]c4c(n3)cccc4

InChI

1S/C22H26FN3O2S/c1-25(22-24-20-4-2-3-5-21(20)29-22)17-10-12-26(13-11-17)14-18(27)15-28-19-8-6-16(23)7-9-19/h2-9,17-18,27H,10-15H2,1H3

Clé InChI

IGMKTIJBFUMVIN-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Neuroprotective and cognition-enhancing (nootropic) benzothiazole derivative that prevents NMDA- and glutamate-induced neurotoxicity.
Sabeluzole is a benzothiazole derivative that exerts neuroprotective and cognition-enhancing (nootropic) efficacy by preventing NMDA- and glutamate-induced neurotoxicity.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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H W Boddeke et al.
Basic research in cardiology, 84(5), 489-498 (1989-09-01)
In the guinea pig heart-lung preparation, the protective effects of nifedipine and R 58735 on cardiovascular alterations following mild (35 min) and severe (60 min) ischemia and reperfusion (30 min) were studied. Nifedipine and R 58735 were equi-protective against the
P J Pauwels et al.
Synapse (New York, N.Y.), 12(4), 271-280 (1992-12-01)
The neuroprotective properties of the cognitive enhancer sabeluzole were investigated in rat brain neuronal cultures derived from the hippocampal formation of 17-day-old rat embryos. Measurement of the neuronal cytoskeletal microtubule-associated protein, MAP2, was used to assess survival of neurons after
R Marrannes et al.
Pharmacology, biochemistry, and behavior, 31(1), 153-162 (1988-09-01)
Unilateral intrastriatal injection of quinolinic acid (2,3 pyridine dicarboxylate; QUIN) in the rat produces episodic barrel rotations and tonic-clonic forepaw movements, lasting for several hours. We investigated whether intraperitoneal posttreatment with anticonvulsants could abolish this phenomenon when it is already
Z Hlinák et al.
Psychopharmacology, 104(4), 505-509 (1991-01-01)
The memory enhancing properties of sabeluzole were evaluated in two experimental paradigms in rats. First, we determined the protective action of sabeluzole against a chlordiazepoxide-induced impairment of habituation. Sabeluzole (5 or 25 mg/kg, SC) was administered 1 h before and
P De Witte et al.
Alcohol (Fayetteville, N.Y.), 6(6), 423-430 (1989-11-01)
Chronic alcohol pulmonary exposure in rats produced a cortical hypervascularization from one to four weeks after the onset of the alcoholization procedure. This alcohol-induced cortical hypervascularization, resembling closely the enhanced cortical vascular network observed in chronologically aged rats as well
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