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Merck
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Key Documents

8.55013

Sigma-Aldrich

NovaSyn®TG Sieber resin

Novabiochem®

Synonyme(s) :

9-Fmoc-amino-xanthen-3-yloxy TG resin

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About This Item

Code UNSPSC :
13111023
Nomenclature NACRES :
NA.22

Niveau de qualité

200

Gamme de produits

NovaSyn® TG
Novabiochem®

Forme

beads

Capacité de réaction

reaction type: Fmoc solid-phase peptide synthesis

Fabricant/nom de marque

Novabiochem®

Application(s)

peptide synthesis

Groupe fonctionnel

amine

Température de stockage

2-8°C

Catégories apparentées

Description générale

NovaSyn TG Sieber resin consists of 130 μm NovaSyn TG bromo resin derivatized with Sieber′s xanhydrylamine linker [1,2]. This resin is ideal for the Fmoc SPPS of partially protected peptide amide fragments. Cleavage from this support is effected by treatment with 1% TFA in DCM, conditions that leave most standard side-chain protecting groups intact. This resin can be reductively alkylated and used to prepare secondary carboxamides [3]. It can also be employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198.
[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.

Liaison

Replaces: 01-64-0092

Remarque sur l'analyse

Color (visual): light yellow to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.10 - 0.25 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is NovaSyn TG resin (130µm)

Informations légales

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocoles

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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