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472301

Sigma-Aldrich

Diméthylsulfoxyde

Dimethyl sulfoxide

ACS reagent, ≥99.9%

Synonyme(s) :

DMSO, Sulfoxyde de méthyle

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Sélectionner une taille de conditionnement

100 ML
137,00 $
500 ML
285,00 $
1 L
371,00 $
2.5 L
1 190,00 $
6 X 500 ML
1 690,00 $
6 X 1 L
1 860,00 $
4 L
1 860,00 $
4 X 4 L
7 000,00 $
4 X 4 L
7 150,00 $
18 L
8 130,00 $

137,00 $


En stockDétails


Devis pour commande en gros

Sélectionner une taille de conditionnement

Changer de vue
100 ML
137,00 $
500 ML
285,00 $
1 L
371,00 $
2.5 L
1 190,00 $
6 X 500 ML
1 690,00 $
6 X 1 L
1 860,00 $
4 L
1 860,00 $
4 X 4 L
7 000,00 $
4 X 4 L
7 150,00 $
18 L
8 130,00 $

About This Item

Formule linéaire :
(CH3)2SO
Numéro CAS:
Poids moléculaire :
78.13
Beilstein:
506008
Numéro CE :
Numéro MDL:
Code UNSPSC :
12191502
ID de substance PubChem :
Nomenclature NACRES :
NA.21
Qualité:
ACS reagent
Essai:
≥99.9%
pb:
189 °C (lit.)
Pression de vapeur:
0.42 mmHg ( 20 °C)

137,00 $


En stockDétails


Devis pour commande en gros

Qualité

ACS reagent

Niveau de qualité

Densité de vapeur

2.7 (vs air)

Pression de vapeur

0.42 mmHg ( 20 °C)

Essai

≥99.9%

Forme

liquid

Température d'inflammation spontanée

573 °F

Limite d'explosivité

42 %, 63 °F

Impuretés

≤0.001 meq/g Titr. acid
≤0.1% water

Résidus d'évap.

≤0.01%

Couleur

clear colorless

Indice de réfraction

n20/D 1.479 (lit.)

pb

189 °C (lit.)

Pf

16-19 °C (lit.)

Densité

1.10 g/mL (lit.)

Chaîne SMILES 

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

Clé InChI

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Description générale

Le diméthylsulfoxyde est un composé organosoufré couramment utilisé comme solvant, capable de dissoudre un large éventail de composés polaires et non polaires. Il est aussi employé comme réactif dans plusieurs procédés bien connus, notamment l'oxydation de Swern, l'oxydation de Pfitzner-Moffatt et la réaction de Corey-Chaykovsky. [1] [2]

Application

Le diméthylsulfoxide (DMSO) a été utilisé :
  • dans la préparation du 4-[18F]fluorobenzoate d'éthyle[3].
  • dans le milieu de culture d'un test au MTT (bromure de 3-(4,5-diméthylthiazol-2-yl)-2,5-diphényltétrazolium)[4].
  • comme solvant en synthèse organique.
  • pour dissoudre et préparer des solutions-mères de petites molécules, médicaments et composés chimiques destinés à divers tests et expériences.

Attention

Refroidit facilement et revient doucement à la température de la pièce. Les produits solides peuvent être reliquéfiés par chauffage à la température ambiante sans abîmer le produit.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F - closed cup

Point d'éclair (°C)

87 °C - closed cup


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Certificats d'analyse (COA)

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Les clients ont également consulté

Dimethyl sulfoxide extraction method for the liquid chromatographic analysis of microencapsulated vitamin D3
Richard P J, et al.
Journal of Agricultural and Food Chemistry, 45, 1784-1786 (1997)
The applications of dimethyl sulfoxide as reagent in organic synthesis
Xiao-Feng W, et al.
Advanced Synthesis & Catalysis, 358, 336-352 (2016)
Shuang Hou et al.
Journal of visualized experiments : JoVE, (52)(52), doi:10-doi:10 (2011-07-07)
Biomolecules, including peptides¹⁻⁹, proteins¹⁰⁻¹¹, and antibodies and their engineered fragments¹²⁻¹⁴, are gaining importance as both potential therapeutics and molecular imaging agents. Notably, when labeled with positron-emitting radioisotopes (e.g., Cu-64, Ga-68, or F-18), they can be used as probes for targeted
P Roy et al.
The FEBS journal, 277(2), 441-452 (2009-12-18)
EVI1 is a nuclear zinc finger protein essential to normal development, which participates in acute myeloid leukaemia progression and transforms Rat1 fibroblasts. In this study we show that enforced expression of Evi1 in Rat1 fibroblasts protects from paclitaxel-induced apoptosis, consistent
Oxidation of alcohols by ?activated? dimethyl sulfoxide. A preparative, steric and mechanistic study.
Omura K and Swern D.
Tetrahedron, 34(11), 1651-1660 (1978)

Articles

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Des substances sont dites miscibles si elles se dissolvent l'une dans l'autre en formant une solution uniforme. Ajoutez à vos marque-pages ou téléchargez notre tableau de miscibilité incluant les solvants de laboratoire courants.

Questions

1–10 of 11 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. I know that this substance is of 2 types, with smell and without smell. What type is this?

    1 answer
    1. This is a high purity DMSO. While odor is not a tested specification, high purity products are expected to be odorless. A disagreeable odor is due to the sulfur moiety in the material. DMSO may also contain small amounts of un-reacted Dimethyl Sulfide (DMS). This DMS is generally contributes to a disagreeable odor.

      Helpful?

  4. Can I use this DMSO for cell freezing?Is it sterile

    1 answer
    1. While DMSO is commonly used as a cryoprotectant in cell freezing, this product has not been tested for use in cell culture. This product is also not sterile. See the links below to review the sterile, cell culture tested DMSO product options:
      D2438, DMSO, sterile-filtered, BioPerformance Certified, meets EP & USP testing specifications, suitable for hybridoma
      https://www.sigmaaldrich.com/product/sigma/d2438

      D2650, sterile-filtered, Bioreagent, suitable for hybridoma
      https://www.sigmaaldrich.com/product/sigma/d2650

      Helpful?

  5. What is the molarity of DMSO?

    1 answer
    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

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  6. Does DMSO have any synthetic utility?

    1 answer
    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

      Helpful?

  7. Is Dimethyl sulfoxide a sterile product?

    1 answer
    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

      Helpful?

  8. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer
    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

  9. Where does DMSO come from?

    1 answer
    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

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  10. What is the DMSO dissolved in?

    1 answer
    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

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1–10 of 11 Questions  

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