V900421
Uridine
Vetec™, reagent grade, 99%
Sinônimo(s):
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
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About This Item
Fórmula empírica (Notação de Hill):
C9H12N2O6
Número CAS:
Peso molecular:
244.20
Beilstein:
754902
Número MDL:
Código UNSPSC:
12352204
ID de substância PubChem:
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
grau
reagent grade
linha de produto
Vetec™
Ensaio
99%
Formulário
powder
pf
163-167 °C (lit.)
cadeia de caracteres SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
chave InChI
DRTQHJPVMGBUCF-XVFCMESISA-N
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Descrição geral
Ações bioquímicas/fisiológicas
Uridine is an essential compound involved in maintaining cellular function and energy metabolism. It aids in multiple biological processes, including RNA synthesis, the synthesis of biomembranes, and glycosylation.[3] Furthermore, uridine serves as a precursor molecule for UDP-glucose, a vital component in the synthesis and storage of glycogen in the liver.[4] In addition, studies have shown that uridine reduces cytotoxicity and improves neurophysiological functions.[2] It is involved in regulating various normal physiological processes in the body, including the cardio-circulatory, reproductive, peripheral and central nervous, and respiratory systems.[5]
Informações legais
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
Laure Jobert et al.
Molecular cell, 49(2), 339-345 (2012-12-19)
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that removes uracil and oxidised pyrimidines from DNA. We show that SMUG1 interacts with the pseudouridine synthase Dyskerin (DKC1) and colocalizes with DKC1 in nucleoli and Cajal bodies.
Che C Colpitts et al.
Journal of virology, 87(7), 3640-3654 (2013-01-04)
Entry of enveloped viruses requires fusion of viral and cellular membranes. Fusion requires the formation of an intermediate stalk structure, in which only the outer leaflets are fused. The stalk structure, in turn, requires the lipid bilayer of the envelope
Juma A M Ali et al.
Molecular pharmacology, 83(2), 439-453 (2012-11-29)
African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis
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