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577515-U

Supelco

Coluna de HPLC Ciano Discovery®

5 μm particle size, L × I.D. 2 cm × 3 mm

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About This Item

Código UNSPSC:
41115700
eCl@ss:
32110501

Materiais

stainless steel column

Agency

suitable for USP L10

linha de produto

Discovery®

Características

endcapped

fabricante/nome comercial

Discovery®

embalagem

1 ea of

Extensão da rotulagem

4.5% Carbon loading

Parâmetros

≤70 °C temp. range
400 bar pressure (5801 psi)

técnica(s)

HPLC: suitable
LC/MS: suitable

C × D.I.

2 cm × 3 mm

área da superfície

200 m2/g

cobertura de superfície

3.5 μmol/m2

Impurezas

<10 ppm metals

matriz

silica gel, high purity, spherical base material
fully porous particle

Grupo ativo da matriz

cyano phase

tamanho de partícula

5 μm

tamanho de poro

180 Å

operating pH range

2-8

aplicação(ões)

food and beverages

técnica de separação

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Características e benefícios

  • Baixa hidrofobicidade para eluição rápida de analitos hidrofóbicos
  • Excelente formato de pico e retenção de analitos fortemente básicos
  • Retenção de analitos polares
  • Seletividade única
  • Significativamente menos retenção que a C18 (geralmente requer fase móvel com menor % orgânica)
  • Separações por LC-MS estáveis, com pouco vazamento
  • Compatível com fases orgânicas altamente aquosas

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Informações legais

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificados de análise (COA)

Lot/Batch Number

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Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at

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Discovery® HPLC Columns for Fast LC-MS Analysis. The Discovery LC-MS line offers short length columns for fast LC-MS analysis that are rugged and dependable. Supelco offers a robust product that withstands column shock due to fast gradient turnaround times.

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