W4262

1400W dihydrochloride

>98%, solid

• Sinônimo(s): N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
• Fórmula empírica (Notação de Hill): C₁₀H₁₅N₃ · 2 HCl
• Número CAS: 214358-33-5
• Peso molecular: 250.17
• Número MDL: MFCD03428622
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278778
• NACRES: NA.77

Propriedades

• Ensaio: >98%
• Formulário: solid
• condição de armazenamento: desiccated
• originador: GlaxoSmithKline
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
• InChI: 1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
• chave InChI: WDJHSQZCZGPGAA-UHFFFAOYSA-N
• Informações sobre genes: human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Descrição

Aplicação

1400W dihydrochloride has been used:

• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat[1]
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction[2]
• to study its efficacy on renal ischemia/ reperfusion injury in rats[3]
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation[4]

Ações bioquímicas/fisiológicas

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Características e benefícios

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)