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199303

Sigma-Aldrich

Resazurina

certified by the Biological Stain Commission

Sinônimo(s):

7-Hidróxi-3H-fenoxazin-3-ona-10-óxido

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About This Item

Fórmula empírica (Notação de Hill):
C12H6NNaO4
Número CAS:
62758-13-8
Peso molecular:
251.17
Beilstein:
3794971
Número CE:
263-718-5
Número MDL:
MFCD00005036
Código UNSPSC:
12171500
ID de substância PubChem:
24851905
NACRES:
NA.47

grau

certified by the Biological Stain Commission

forma

powder

composição

Dye content, 75%

solubilidade

1 M NH4OH: 1 mg/mL

λmax

380 nm (2nd)
598 nm

aplicação(ões)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1

InChI

1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1

chave InChI

IVGPGQSSDLDOLH-UHFFFAOYSA-M

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Descrição geral

Resazurin is a small N-oxide derivative of dihydroxyphenoxazone. It is a non-ionic dye containing a small and planar chromophore. It is a redox indicator and changes from bluish violet through pink to colorless upon reduction. It is also used as a pH indicator for Ph 3.5 to 6.5 wherein it changed from orange to bluish violet. It is commercially available as resazurin sodium salt, which is also known as 3H-Phenoxazin-3-one, 7-hydroxy-, 10-oxide, sodium salt. It forms the red, fluorescent hydroxyphenoxazone resorufin on reduction and colorless hydroresorufin on further reduction.

Aplicação

Resazurin is mostly used as a biological redox indicator. The bioreduction of the dye reduces the amount of the oxidized form (blue) and concomitantly increases the fluorescent intermediate (red). Its applications include:
  • the measurement of metabolic activity and the proliferation of living cells
  • the detection of bacterial reduction in milk
  • in viability assays as a component of culture media for the detection of viable bacteria
  • to determine the number of motile sperm in sheep semen
  • to assay lactate dehydrogenase
  • as an analytical reagent to quantify L-glutamate
Para medição da atividade metabólica e proliferação de células vivas. A biorredução do corante reduz a quantidade da forma oxidada (azul) e aumenta, concomitantemente, o intermediário fluorescente (vermelho).

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appropriate E3 ligase for the target protein, improving the binding affinities towards the target protein and the E3 ligase, and optimizing the PROTAC linker. However, due
Conn?s Biological Stains: A Handbook of Dyes, Stains and Fluorochromes for Use in Biology and Medicine (10th ed.)
R. W. Horobin and J. A. Kiernan (Eds.)
Conn?s Biological Stains (2002)
Morris E Feldman et al.
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