V3388
Vascular Endothelial Growth Factor (aa 207-318) human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinônimo(s):
VEGF112, Vasculotropin
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5 μG
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5 μG
R$ 5.628,00
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R$ 5.628,00
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Nome do produto
Vascular Endothelial Growth Factor (aa 207-318) human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
≥97% (SDS-PAGE)
Formulário
lyophilized powder
potência
0.75-3.75 ng/mL ED50
peso molecular
predicted mol wt ~28 kDa
embalagem
pkg of 5 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
Impurezas
<1 EU/μg
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... VEGFA(7422)
Aplicação
Vascular Endothelial Growth Factor (aa 207-318) human also known as VEGF 121 was used for preparing a cellular matrix hybridized with hyaluronic acid (ACM-HA) VEGF constructs which is used in measuring the VEGF-enhanced tissue-engineered bladder graft neovascularization by using dynamic contrast-enhanced MRI.[1] The product was used for creating VEGF-impregnated tissue-engineered construct which was inserted in the critical-sized calvarial defect in the membranous parietal bone of the rabbit for examining and characterizing the angiogenesis necessary for bone formation.[2]
Ações bioquímicas/fisiológicas
Potent angiogenesis inducer in vivo.
Vascular Endothelial Growth Factor (aa 207-318) human also referred to as VEGF 121 or Vasculotropin is a basic protein that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF also enhances the growth of endothelial cells isolated from cerebral cortex, fetal and adult aorta as well as human umbilical vein.[3] Cells enhance VEGF 121 secretion from fibrin implants results in local and controlled blood vessel growth.[4]
Outras notas
112 amino acid residue variant of human VEGF.
forma física
Lyophilized from a 0.2 μm filtered solution in 30% acetronitrile and 0.1% TFA containing 0.25 mg bovine serum albumin.
Nota de análise
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Leung, D.W., et al.
Science, 246 (1989)
Sevan Evren et al.
Cells, tissues, organs, 192(4), 250-261 (2010-07-01)
Natural scaffolds have been shown to induce T helper 2 (TH2)-specific immune responses in host tissues; however, the precise mechanisms that underlie this immune response are unknown. Using a porcine animal model, we evaluated the role of Toll-like receptors (TLRs)
Lisa Cartwright et al.
Journal of biomedical materials research. Part A, 77(2), 390-395 (2006-01-24)
Tissue engineered organs require an immediately perfused vascular tree. Currently, neovascularization assessment requires animal sacrifice and graft harvest. In this pilot study we assess whether neovascularization of an engineered urinary bladder construct is enhanced with vascular-derived endothelial growth factor (VEGF)
Martin Ehrbar et al.
Circulation research, 94(8), 1124-1132 (2004-03-27)
Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF
Marine Beaumont et al.
NMR in biomedicine, 23(1), 48-55 (2009-08-04)
Tissue engineering is a promising technique for bone repair and can overcome the major drawbacks of conventional autogenous bone grafting. In this in vivo longitudinal study, we proposed a new tissue-engineering paradigm: inserting a biological soft-tissue construct within the bone
Artigos
VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.
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