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V1255

Sigma-Aldrich

D-Valine

suitable for cell culture, BioReagent

Sinônimo(s):

(R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid

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About This Item

Fórmula linear:
(CH3)2CHCH(NH2)CO2H
Número CAS:
640-68-6
Peso molecular:
117.15
Beilstein:
1721135
Número CE:
211-368-9
Número MDL:
MFCD00064219
Código UNSPSC:
12352209
ID de substância PubChem:
24900713
NACRES:
NA.75
Preço e disponibilidade não estão disponíveis no momento.

fonte biológica

synthetic (organic)

linha de produto

BioReagent

Formulário

powder

técnica(s)

cell culture | mammalian: suitable

pf

>295 °C (subl.) (lit.)

Condições de expedição

ambient

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CC(C)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

chave InChI

KZSNJWFQEVHDMF-SCSAIBSYSA-N

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Descrição geral

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Aplicação

D-Valine has been used as a supplement in:
  • Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture[1]
  • endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture[2]
  • DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture[3]

Ações bioquímicas/fisiológicas

D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.[4]
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000375491
0000375491
SLCM9126
SLCJ8797
SLCF1697

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S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
Phillip C Calder
The Journal of nutrition, 136(1 Suppl), 288S-293S (2005-12-21)
Although there has been great interest in the effects of amino acids on immune function, little is known about the impact of changes in BCAA availability on the ability of the immune system to function. Human immune cells incorporate BCAA
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
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