This product may be reconstituted in 0.01M phosphate buffer at pH 7.5. Stock solutions, prepared at 10 micro IU per milliliter, may be stored frozen in aliquots. Avoid repeated freeze/thaw cycles. Working solutions should be prepared fresh and not stored.
T9265
Thyrotropic hormone from human pituitary
lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
Sinônimo(s):
hTSH, TSH, Thyroid stimulating hormone
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Selecione um tamanho
5 μG
R$ 1.536,00
10 μG
R$ 2.637,00
25 μG
R$ 5.264,00
0.1 MG
R$ 17.538,00
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Alterar visualização
5 μG
R$ 1.536,00
10 μG
R$ 2.637,00
25 μG
R$ 5.264,00
0.1 MG
R$ 17.538,00
About This Item
Produtos recomendados
fonte biológica
human pituitary glands
Nível de qualidade
esterilidade
non-sterile
Formulário
lyophilized powder
atividade específica
≥6.2 IU/mg (immunoassay, non-sterile)
condição de armazenamento
(Keep container tightly closed in a dry and well-ventilated place)
técnica(s)
cell culture | mammalian: suitable
Impurezas
HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative
Condições de expedição
ambient
temperatura de armazenamento
2-8°C
Informações sobre genes
human ... TSHB(7252) , TSHR(7253)
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Descrição geral
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Aplicação
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation.[3] It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.[4]
Ações bioquímicas/fisiológicas
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment.[5] Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.[6]
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.[7]TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins.[8] In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).[9]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Embalagem
Package size based on hormone
forma física
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
anticorpo
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Physiology, Thyroid Stimulating Hormone
Pirahanchi Y, et al.
StatPearls [Internet] (2022)
J Carretero et al.
Histology and histopathology, 4(1), 71-76 (1989-01-01)
The TSH-producing adenohypohyseal cells of Wistar rats were studied after treatment with orally administered methymazole by the PAP immunocytochemical method. These cells were compared with those of normal animals. The effects of methymazole were different in the females to those
Zhenghao Wu et al.
Journal for immunotherapy of cancer, 10(1) (2022-02-02)
Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. The source
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