P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

• Sinônimo(s): L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide
• Fórmula empírica (Notação de Hill): C₁₆H₂₂N₆O₄
• Número CAS: 24305-27-9
• Peso molecular: 362.38
• Beilstein: 770238
• Número CE: 246-143-4
• Número MDL: MFCD00038640
• Código UNSPSC: 51111800
• ID de substância PubChem: 24898185
• NACRES: NA.32

Propriedades

• fonte biológica: human
• Ensaio: ≥98% (HPLC)
• forma: powder
• peso molecular: 362.38
• condição de armazenamento: (Keep container tightly closed in a dry and well-ventilated place)
• técnica(s): activity assay: suitable
• Impurezas: 22.6-23.8% Nitrogen; 51.9-54.1% carbon
• solubilidade: water: 25 mg/mL, cloudy, colorless to faintly yellow
• nº de adesão UniProt: P20396; P21761; P34981
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• chave InChI: XNSAINXGIQZQOO-SRVKXCTJSA-N
• Informações sobre genes: human ... TRH(7200) , TRHR(7201) ; mouse ... Trhr(22045)

Descrição

Amino Acid Sequence

Glp-His-Pro-NH2

Descrição geral

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.

Aplicação

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.

Ações bioquímicas/fisiológicas

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)