T8951

Tangeretin

≥95% (HPLC)

• Sinônimo(s): 4′,5,6,7,8-Pentamethoxyflavone, 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, NSC 53909, NSC 618905, Ponkanetin
• Fórmula empírica (Notação de Hill): C₂₀H₂₀O₇
• Número CAS: 481-53-8
• Peso molecular: 372.37
• Beilstein: 351695
• Número CE: 207-570-1
• Número MDL: MFCD00017438
• Código UNSPSC: 12352205
• ID de substância PubChem: 329826890
• NACRES: NA.25

Propriedades

• Ensaio: ≥95% (HPLC)
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• cadeia de caracteres SMILES: COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
• chave InChI: ULSUXBXHSYSGDT-UHFFFAOYSA-N

Descrição

Descrição geral

Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.[1][2]

Aplicação

Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae.[3] It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.[4]

Ações bioquímicas/fisiológicas

Tangeretin displays its anti-cancer effects by modulating different pathways in several cancer types in both in-vitro and in-vivo studies.[1][2] It also exerts antioxidant, anti-inflammatory, and estrogenic properties.[2]

Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges