T2752

3,3′,5-Triiodo-L-thyronine sodium salt

≥95% (HPLC)

• Sinônimo(s): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Fórmula empírica (Notação de Hill): C₁₅H₁₁I₃NNaO₄
• Número CAS: 55-06-1
• Peso molecular: 672.96
• Beilstein: 8179867
• Número CE: 200-223-5
• Número MDL: MFCD00002594
• Código UNSPSC: 51111800
• ID de substância PubChem: 24900071
• NACRES: NA.32

Propriedades

• fonte biológica: synthetic (organic)
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• solubilidade: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• chave InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Informações sobre genes: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Descrição

Aplicação

3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells.[1] The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.[2]

Ações bioquímicas/fisiológicas

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function.[3] The product also positively regulates the hepatic FGF21 expression[4] and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.

Nota de preparo

3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)