SRP6158
EPO human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Sinônimo(s):
EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in HEK 293 cells
Ensaio
≥95% (SDS-PAGE)
forma
lyophilized
peso molecular
36 kDa (monomer, glycosylated)
embalagem
pkg of 10 μg
técnica(s)
cell culture | mammalian: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... EPO(2056)
Descrição geral
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.
Aplicação
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
- It has also been used as a component of endothelial differentiation medium.
Ações bioquímicas/fisiológicas
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.
forma física
Lyophilized from a PBS solution.
Nota de preparo
Centrifuge the vial prior to opening.
Reconstituição
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
Tessa Wilkin et al.
Drug testing and analysis, 9(9), 1456-1471 (2017-03-30)
A horse's success on the racetrack is determined by genetics, training and nutrition, and their translation into physical traits such as speed, endurance and muscle strength. Advances in genetic technologies are slowly explaining the roles of specific genes in equine
Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.
Fang B, et al.
Blood, 105, 2733-2740 (2005)
PlanHab: Hypoxia counteracts the erythropoietin suppression, but seems to exaggerate the plasma volume reduction induced by 3 weeks of bed rest.
Keramidas ME, et al.
Physiological Reports, 4, e12760-e12760 (2016)
Luis Toro et al.
Kidney international, 93(5), 1131-1141 (2018-02-06)
It is accepted that osteoblasts/osteocytes are the major source for circulating fibroblast growth factor 23 (FGF23). However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in bone marrow and potential contribution to circulating FGF23 has
Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia.
Kawakami M, et al.
The Journal of Biological Chemistry, 276, 39469-39475 (2001)
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica