SRP4702
CTGF human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinônimo(s):
connective tissue growth factor
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About This Item
Preço e disponibilidade não estão disponíveis no momento.
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fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥95% (HPLC)
≥95% (SDS-PAGE)
Formulário
lyophilized
potência
501.0-2.0 μg/mL ED50
peso molecular
~11.2 kDa
embalagem
pkg of 20 μg
Impurezas
endotoxin, tested
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... CTGF(1490)
Descrição geral
The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2.[1] CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells.[2][3][4] The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT).[2] It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta.[4] Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.
Ações bioquímicas/fisiológicas
CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells.[5][6][7] It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy.[3] It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.[8]
forma física
Sterile filtered and Lyophilized without additives.
Reconstituição
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Hsiao-Chi Tsai et al.
Oncotarget, 5(11), 3800-3812 (2014-07-09)
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Nishida T, et al.
Journal of Cellular Physiology, 184, 197-206 (2000)
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Kikuchi R, et al.
Cancer Research, 67, 7095-7105 (2007)
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Wang S, et al.
Journal of Diabetes Research, 2015, 962383-962383 (2015)
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Zhu X, et al.
Oncotarget, 6, 25320-25338 (2015)
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