SML3842

TAT-SAMβA trifluoroacetate

≥95% (HPLC)

• Sinônimo(s): SAMβA trifluoroacetate, TAT(47-57)-GG-βIIPKC(624-632) trifluoroacetate, TAT(47-57)-GG-SAMβA trifluoroacetate, YGRKKRRQRRR-GG-RNAENFDRF trifluoroacetate
• Fórmula empírica (Notação de Hill): C₁₁₈H₁₉₅N₅₁O₃₁ · xC₂HF₃O₂
• Peso molecular: 2824.13 (free base basis)
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: (Powder or Lyophilized powder or film)
• condição de armazenamento: desiccated
• cor: white to off-white
• temperatura de armazenamento: -10 to -25°C

Descrição

Ações bioquímicas/fisiológicas

Mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1.

TAT-SAMβA is a mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1. TAT-SAMβA protects neonatal and adult rat cardiac myocytes, but not Mfn1-knockout cells, from stress-induced death in cultures and improves cardiac contractility in rats with heart failure in vivo (3 mg/kg/day for 6 wks via Alzet pump delivery) by re-establishing mitochondrial morphology and function. TAT-SAMβA is composed of a 9-aa βIIPKC-derived MFN1-interacting sequence linked at the N-terminal to the cell permeable TAT(47-57) via a -Gly-Gly- spacer

Atenção

Hygroscopic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable