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SML0543

Sigma-Aldrich

p38 MAP Kinase Inhibitor IV

≥98% (HPLC)

Sinônimo(s):

2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol), B10, MT4

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R$ 611,00

About This Item

Fórmula empírica (Notação de Hill):
C12H4Cl6O4S
Número CAS:
1638-41-1
Peso molecular:
456.94
Código UNSPSC:
12352200
NACRES:
NA.77

R$ 611,00

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Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL, clear (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[S](=O)(=O)(c2c(c(cc(c2O)Cl)Cl)Cl)c1c(c(cc(c1O)Cl)Cl)Cl

InChI

1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

chave InChI

AKUKHICVNCCQHN-UHFFFAOYSA-N

Aplicação

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.[1]

Ações bioquímicas/fisiológicas

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK.

Características e benefícios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000158495
0000158495
0000158494
0000124260

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Sigma-Aldrich

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Artigos

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

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