This product is a research grade Itopride and not considered a primary or secondary standard. Currently, there is no primary standard product available.
SML0033
Itopride hydrochloride
≥98% (HPLC)
Sinônimo(s):
N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
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10 MG
R$ 728,00
50 MG
R$ 2.915,00
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10 MG
R$ 728,00
50 MG
R$ 2.915,00
About This Item
Fórmula empírica (Notação de Hill):
C20H26N2O4 ·HCl
Número CAS:
Peso molecular:
394.89
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Ensaio
≥98% (HPLC)
Formulário
powder
condição de armazenamento
desiccated
cor
white to tan
solubilidade
H2O: ≥48 mg/mL
originador
Abbott
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
InChI
1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
chave InChI
ZTOUXLLIPWWHSR-UHFFFAOYSA-N
Descrição geral
Itopride hydrochloride is a new prokinetic drug.[1]
Ações bioquímicas/fisiológicas
Antagonist of dopamine D2-receptor with anticholinesterase activity.
Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.[1]
Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.
Características e benefícios
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Aquatic Acute 1 - Aquatic Chronic 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Os clientes também visualizaram
Y Iwanaga et al.
Japanese journal of pharmacology, 56(3), 261-269 (1991-07-01)
To estimate the effect of a new gastroprokinetic agent, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803), on non-ulcer dyspepsia, the influence of HSR-803 on gastrointestinal propulsion was assayed in dogs, rats and mice in comparison with some gastroprokinetic agents. HSR-803 (30 mg/kg, p.o.) significantly
Y Iwanaga et al.
Gastroenterology, 99(2), 401-408 (1990-08-01)
A novel water-soluble dopamine-2 antagonist, N-[4-[2-(dimethylamino) ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) was synthesized and assayed for its gastrointestinal smooth muscle stimulating activity in vivo and in vitro. In the in vivo study, gastrointestinal contractile activity was measured by means of chronically implanted
E Takahara et al.
Journal of chromatography, 576(1), 174-178 (1992-04-15)
A method based on high-performance liquid chromatography using column-switching is described for the simultaneous determination of HSR-803 and its metabolites in human serum and urine. The system uses a six-port valve with a Nucleosil CN pre-column for on-line sample clean-up
Sanjay Bansal et al.
Drug delivery, 23(2), 437-451 (2014-05-29)
The objectives of present studies were to develop the systematically optimized multiple-unit gastroretentive microballoons, i.e. hollow microspheres of itopride hydrochloride (ITH) employing quality by design (QbD)-based approach. Initially, the patient-centric QTPP and CQAs were earmarked, and preliminary studies were conducted
[Effect of HSR-803 on gastrointestinal motility].
H Iwanaga et al.
Nihon Heikatsukin Gakkai zasshi, 25(6), 313-315 (1989-12-01)
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Is the Itopride HCL CAS 122892-31-3 a primary standard grade or a reagent grade?
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