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SAB4200698

Sigma-Aldrich

Anti-MR-Pro ADM antibody, Mouse monoclonal

clone 2E12E6, purified from hybridoma cell culture

Sinônimo(s):

Midregional proadrenomedullin

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About This Item

Código UNSPSC:
51111800
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

200

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

2E12E6, monoclonal

forma

buffered aqueous solution

peso molecular

antigen 5 kDa

reatividade de espécies

human

concentração

~1 mg/mL

técnica(s)

immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92).
indirect ELISA: 30-60 ng/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92) for coating.

Isotipo

IgG1

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ADM (133)

Descrição geral

Monoclonal Anti-MR-Pro ADM (mid-regional pro adrenomedullin) (mouse IgG1 isotype) is derived from the hybridoma 2E12E6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human recombinant protein. Mid-regional pro-adrenomedullin (MR-proADM) is obtained as a by-product of post-translational processing of prepro adrenomedullin (Adm, AM) peptide. This gene is located on human chromosome 11p15.

Imunogênio

human MR-Pro ADM recombinant protein.

Aplicação

Anti-MR-pro ADM has been used in immunoblotting (~5 kDa) and indirect enzyme-linked immunosorbent assay (ELISA).

Ações bioquímicas/fisiológicas

Mid-regional pro-adrenomedullin (MR-proADM) has been suggested as a biomarker for plasma concentrations of adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Upregulated levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. It can stimulate vascular endothelial barrier function.

forma física

a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
Matson BC, et al.
Fertility and Sterility, 109(6), 1072-1078 (2018)
Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review
Healthcare (Basel, Switzerland) , 6(3), 110-110 (2018)
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease)
Xie Z, et al.
Journal of Leukocyte Biology, 103(4), 749-759 (2018)
Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population
Glorioso N, et al.
PLoS ONE, 8(10), e77562-e77562 (2013)
Mihael Potocki et al.
Current heart failure reports, 9(3), 244-251 (2012-06-27)
Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as

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