Q2128

Quisqualic acid

powder

• Sinônimo(s): β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
• Fórmula empírica (Notação de Hill): C₅H₇N₃O₅
• Número CAS: 52809-07-1
• Peso molecular: 189.13
• Beilstein: 1078734
• Número MDL: MFCD00069337
• Código UNSPSC: 12352106
• ID de substância PubChem: 24278004
• NACRES: NA.32

Propriedades

• Formulário: powder
• Nível de qualidade: 200
• cor: white to off-white
• solubilidade: ethanol: <0.17 mg/mL; H₂O: 0.5 mg/mL; 0.1 M HCl: 1.4 mg/mL; 1 M NH4OH: 20 mg/mL; organic solvents: insoluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: N[C@@H](CN1OC(=O)NC1=O)C(O)=O
• InChI: 1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
• chave InChI: ASNFTDCKZKHJSW-REOHCLBHSA-N
• Informações sobre genes: rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418)

Descrição

Descrição geral

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.[1][2]

Aplicação

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.[3]

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.[4]

Ações bioquímicas/fisiológicas

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves