P9018
Phorbol 12,13-didecanoate
solid
Sinônimo(s):
PDD, Phorbol 12,13-dicaprinate
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About This Item
Fórmula empírica (Notação de Hill):
C40H64O8
Número CAS:
Peso molecular:
672.93
Beilstein:
6036113
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
Produtos recomendados
Formulário
solid
cor
white
solubilidade
DMSO: soluble
ethanol: soluble
methanol: soluble
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C
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Descrição geral
More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent
Ações bioquímicas/fisiológicas
Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.
Atenção
Photosensitive
Reconstituição
A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.
Código de classe de armazenamento
13 - Non Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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K Hu et al.
The American journal of physiology, 276(2 Pt 2), H488-H495 (1999-02-10)
Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity
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Schizophrenia bulletin, 41(3), 744-753 (2014-10-22)
Nuclear distribution E homolog 1 (NDE1), located within chromosome 16p13.11, plays an essential role in microtubule organization, mitosis, and neuronal migration and has been suggested by several studies of rare copy number variants to be a promising schizophrenia (SCZ) candidate
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There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(1), 67-74 (2014-09-15)
Periodontal disease (PDD) was associated with inflammation, malnutrition, and higher mortality in hemodialysis (HD) patients. Cross-sectional observational study, aiming to assess the prevalence of PDD and the possible relationship among PDD, inflammation, and malnutrition in HD patients. Single HD center
Xin Ma et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(4), 851-858 (2010-01-23)
The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx. Hemodynamic blood flow is an important physiological factor that modulates vascular tone. One critical early
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