P7903

Pipemidic acid

• Sinônimo(s): 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid
• Fórmula empírica (Notação de Hill): C₁₄H₁₇N₅O₃
• Número CAS: 51940-44-4
• Peso molecular: 303.32
• Número CE: 257-530-2
• Número MDL: MFCD00057291
• Código UNSPSC: 51282938
• ID de substância PubChem: 24898889
• NACRES: NA.85

Propriedades

• forma: powder
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: DNA synthesis | interferes; cell wall synthesis | interferes; enzyme | inhibits
• cadeia de caracteres SMILES: CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3
• InChI: 1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
• chave InChI: JOHZPMXAZQZXHR-UHFFFAOYSA-N
• Informações sobre genes: human ... CYP1A2(1544)

Descrição

Descrição geral

Chemical structure: quinolone

Aplicação

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Ações bioquímicas/fisiológicas

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Nota de análise

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Outras notas

10g,100g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H317,H334
• Declarações de precaução: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Classificações de perigo: Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves