P7769

1,2-Diacyl-sn-glycero-3-phospho-L-serine

from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid

• Sinônimo(s): 3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: 1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
• fonte biológica: bovine brain
• Ensaio: ≥97% (TLC)
• Formulário: amorphous powder
• temperatura de armazenamento: −20°C

Descrição

Aplicação

1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:

• as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints[1]
• as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts[2]
• as a component of large unilamellar vesicles for annexin A2 aggregation studies[3]

Ações bioquímicas/fisiológicas

1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia.[4] PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria.[5] The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum.[6] PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.[7]

A slowly metabolized structural phospholipid found mainly in gray matter.

Características e benefícios

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Solutions exposed to room temperature will decompose about 0.5% per day.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)