P5296

CTOP

≥97% (HPLC)

• Fórmula empírica (Notação de Hill): C₅₀H₆₇N₁₁O₁₁S₂
• Número CAS: 103429-31-8
• Peso molecular: 1062.26
• Número MDL: MFCD00076708
• Código UNSPSC: 12352200
• ID de substância PubChem: 329820226
• NACRES: NA.77

Propriedades

• Ensaio: ≥97% (HPLC)
• Formulário: powder
• nº de adesão UniProt: Q64387
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O
• InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1
• chave InChI: PZWWYAHWHHNCHO-FGHAYEPSSA-N
• Informações sobre genes: mouse ... Pnoc(18155)

Descrição

Amino Acid Sequence

Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr-NH2 [Disulfide Bridge: 2-7]

Descrição geral

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.[1]

Aplicação

CTOP has been used:

• to study the anxiogenic effects induced by CTOP in mice and rat.[2]
• to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.[3]
• to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).[4]

Ações bioquímicas/fisiológicas

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) inhibits acute morphine-induced hypermotility and analgesic effect of morphine in a dose-dependent manner in vivo.[1]

Selective ligand for μ-opioid receptors.

Ligação

Somatostatin analog

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)