05-23-1200

Neurotensin

Potent hypothalamic peptide neurotransmitter.

• Sinônimo(s): Neurotensin, NT, NTS, Pyr-LYENKPRRPYIL
• Fórmula empírica (Notação de Hill): C₇₈H₁₂₁N₂₁O₂₀
• Número CAS: 39379-15-2
• Peso molecular: 1672.92
• Número MDL: MFCD00080064
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: lyophilized solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white to off-white
• solubilidade: 5% acetic acid: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N3(C(CCC3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N4C(CCC4)C(=O)NC(Cc5ccc(cc5)O)C(=O)NC(C(CC)C)C(=O)NC(CC(C)C)C(=O)O)C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CC2)CC(C)C)Cc1ccc(cc1)O)CCC(=O)O)CC(=O)N)CCCCN
• InChI: 1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
• chave InChI: PCJGZPGTCUMMOT-UHFFFAOYSA-N

Descrição

Descrição geral

Neurotensin (NT), a 13-amino acid peptide neurotransmitter encoded by the NTS gene. NT is located in the gastrointestinal tract and heterogeneously distributed in the mammalian central nervous system, and has many neurotransmitter-like characteristics. It influences various central and peripheral functions by interacting with three neurotensin receptors. It is linked to the modulation of dopaminergic systems and in the induction of changes in behavior, muscle relaxation, nociception, and hypothermia[1], as well as appetite, learning, memory, and fat metabolism.[2] Moreover, it is a modulator of noradrenergic activity. It also acts as an endogenous anti-psychotic compound and lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone, and prolactin in rats. Additionally, it regulates the release of pituitary hormones from the brain and insulin, glucagon, and somatostatin from the gut.[3]

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Modulator of noradrenergic activity

Product does not compete with ATP.

Reversible: no

Embalagem

Yes

Advertência

Toxicity: Standard Handling (A)

Sequência

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

Outras notas

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable